Advances in proteomics in diffuse large B‑cell lymphoma (Review)

  • Authors:
    • Zihan Guo
    • Chenchen Wang
    • Xinyi Shi
    • Zixuan Wang
    • Jingyi Tao
    • Jiaying Ma
    • Lintao Bi
  • View Affiliations

  • Published online on: May 9, 2024     https://doi.org/10.3892/or.2024.8746
  • Article Number: 87
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Diffuse large B‑cell lymphoma (DLBCL) is the most common pathological type of non‑Hodgkin's lymphoma. Although the development of monoclonal antibodies, small‑molecule‑targeted drugs and novel chemotherapeutic agents, and the increased use of immunotherapy have markedly improved the outcomes of DLBCL, ~40% of patients cannot be cured following the use of standardized first‑line treatment. In addition, the specific mechanisms of drug resistance and potential factors associated with a poor prognosis in these patients remain unclear. Proteomics research is used to determine potential associations between changes in DLBCL protein expression levels and different stages of disease occurrence and development. Proteomics may aid in the identification of novel molecular mechanisms and drug resistance mechanisms, through identifying multiple associated proteins and monitoring changes in expression levels. Thus, proteomics research may exhibit potential in the development of therapeutic targets and in improving prognostic evaluation in patients with DLBCL. The present study aimed to review the use of proteomic methods for the investigation of DLBCL, including the mechanisms underlying disease progression and drug resistance in DLBCL, and the function of the tumor microenvironment in lymphoma growth. The present review also demonstrated the potential of proteomic‑guided therapeutic strategies for DLBCL and discussed the synergistic benefits of using proteomic methods in DLBCL research.
View Figures
View References

Related Articles

Journal Cover

June-2024
Volume 51 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo Z, Wang C, Shi X, Wang Z, Tao J, Ma J and Bi L: Advances in proteomics in diffuse large B‑cell lymphoma (Review). Oncol Rep 51: 87, 2024
APA
Guo, Z., Wang, C., Shi, X., Wang, Z., Tao, J., Ma, J., & Bi, L. (2024). Advances in proteomics in diffuse large B‑cell lymphoma (Review). Oncology Reports, 51, 87. https://doi.org/10.3892/or.2024.8746
MLA
Guo, Z., Wang, C., Shi, X., Wang, Z., Tao, J., Ma, J., Bi, L."Advances in proteomics in diffuse large B‑cell lymphoma (Review)". Oncology Reports 51.6 (2024): 87.
Chicago
Guo, Z., Wang, C., Shi, X., Wang, Z., Tao, J., Ma, J., Bi, L."Advances in proteomics in diffuse large B‑cell lymphoma (Review)". Oncology Reports 51, no. 6 (2024): 87. https://doi.org/10.3892/or.2024.8746